Our protocol for localization of T cell clones using the Visium platform is published in STAR Protocols
Our protocol for localization of T cell clones using the Visium platform is published in STAR Protocols. This protocol is a step-by-step guide on how to use a popular spatial transcriptomics platform to visualize the location of antigen-specific T cells directly within tissue. See our recent work in Cell Reports Medicine for our implementation of this technique in brain tumors.
The Cancer Prevention and Research Institute of Texas (CPRIT) has awarded a $2 million grant to the Hudson Lab! This five-year award will fund research in the laboratory to characterize CD8+ T cell responses in human tumors and develop new immunotherapies to improve immune responses to cancer . Read more here.
Our work describing the CD8+ T cell infiltrate of brain metastasis is published today in Cell Reports Medicine! We show that metastatic brain tumors harbor lots of T cells, making them excellent targets for immunotherapy. Our work is also the first to use spatial TCR sequencing, allowing us to track individual T cell clones within tumor tissue! See also Emory University’s press release here.
We are proud to contribute to the publication of a review article on the role of non-coding RNAs in T cell function. Non-coding RNAs are an abundant gene class that are actively regulated and transcribed but do not generate proteins. We discuss the roles of these genes in the generation of T cell memory.